Evidence for the Selective Reporting of Analyses and Discrepancies in Clinical Trials:
Plosmedicine: 6/24/14 A Systematic Review of Cohort Studies of Clinical Trials Abstract Background Most publications about selective reporting in clinical trials have focussed on outcomes. However, selective reporting of analyses for a given outcome may also affect the validity of findings. If analyses are selected on the basis of the results, reporting bias may occur. […]
NYU Researchers Tackle Racial/Ethnic Disparities in HIV Medical Studies
Nyu.edu: July 7, 2014 First social/behavioral intervention to address under-representation of African Americans and Latinos in AIDS clinical trials A New York University College of Nursing (NYUCN) research team found that a social/behavioral intervention vastly increased the number of African American and Latino individuals living with HIV/AIDS who enrolled in HIV/AIDS medical studies. The intervention, […]
More women, minorities needed in clinical trials
Myajc: July 3, 2014 Atlanta will play a key role in a new national campaign to increase the ranks of women, African-Americans, Latinos and Asians in clinical trials. Read More
Clinical Trial Transparency — Antidote to Weaker Off-Label-Promotion Rules?
NEJM: July 3, 2014 This year promises to be an auspicious period for some long-running battles over the dissemination of biomedical research. Some companies seeking more freedom to promote their products have bristled at recent guidance documents from the Food and Drug Administration (FDA) regarding promotion of drugs and devices for off-label uses, claiming that […]
Public-Private Partnerships Can Serve as Important Levers of Innovation
Phrma.org: 07.02.14 Collaboration was a central theme of the recent BIO International Convention, which featured panel discussions on AMP-lifying Innovation: NIH, Patient Organizations & Leading Biopharma Firms Mobilize to Tackle Tough Diseases and Playing Nice in the Sandbox: Pre-Competitive Research Consortiums Offer Quicker, Less Expensive Path to Better Medicines. Accelerating Medicines Partnership Aims to Speed Validation of Disease Targets […]
The Intention-to-Treat Principle
JAMA Guide to Statistics and Methods | July 2, 2014 How to Assess the True Effect of Choosing a Medical Treatment The intention-to-treat (ITT) principle is a cornerstone in the interpretation of randomized clinical trials (RCTs) conducted with the goal of influencing the selection of medical therapy for well-defined groups of patients. The ITT principle defines both […]
Available, accessible, aware, appropriate, and acceptable: a strategy to improve participation of teenagers and young adults in cancer trials
The Lancet:7/1/14 Under-representation of teenagers and young adults in clinical trials for cancer is acknowledged internationally and might account for the lower survival gains noted for this group. Little research has focused on strategies to increase participation of teenagers and young adults in clinical trials. We applied a conceptual framework for barriers to recruitment of […]